RT Journal Article SR Electronic T1 Trimethoprim: laboratory and clinical studies JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 202 OP 209 DO 10.1136/jcp.21.2.202 VO 21 IS 2 A1 J. H. Darrell A1 L. P. Garrod A1 Pamela M. Waterworth YR 1968 UL http://jcp.bmj.com/content/21/2/202.abstract AB Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal. Studies are described of suitable cultural conditions, methods of testing sensitivity, and acquired resistance. Some clinical results of its use are reported in respiratory tract infections, Gram-negative septicaemia, and urinary tract infections, and further therapeutic possibilities are discussed.