RT Journal Article
SR Electronic
T1 Histochemical investigation of acid mucosubstances in secondary amyloidosis
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 578
OP 581
DO 10.1136/jcp.21.5.578
VO 21
IS 5
A1 C. A. Pennock
A1 J. Burns
A1 G. Massarella
YR 1968
UL http://jcp.bmj.com/content/21/5/578.abstract
AB Sections of liver and spleen from six cases of secondary amyloidosis have been examined, by various improved histochemical methods, for acidic mucosubstances. The results indicate a complex in amyloid deposits of protein and sulphated mucopolysaccharides in which the principal substance is heparan sulphate with traces of chondroitin sulphates. Deposits also contain sialic acid. The results are compared with chemical analyses of the same tissues and isolated fibrils which confirm the presence of heparan sulphate, chondroitin sulphates, and a sialic acid containing protein.