@article {Lundvall704, author = {Ove Lundvall and Lennart Enerb{\"a}ck}, title = {Hepatic fluorescence in porphyria cutanea tarda studied in fine needle aspiration biopsy smears}, volume = {22}, number = {6}, pages = {704--709}, year = {1969}, doi = {10.1136/jcp.22.6.704}, publisher = {BMJ Publishing Group}, abstract = {Fine needle aspiration biopsy smears from 19 patients with porphyria cutanea tarda were studied by fluorescence microscopy. Fluorescence was arbitrarily graded from 0 to 4. All patients{\textemdash}those with clinically manifest as well as those with latent disease{\textemdash}showed bright red fluorescence of porphyrin type in the liver cells, though in latent cases the fluorescence commonly was of a low grade. In patients with manifest disease fluorescence of grade 3 or 4 was present. In patients with fluorescence of grades 1 or 2 the uroporphyrin excretion in urine was normal or slightly increased. At higher grades all levels of porphyrin excretion were encountered. Of 22 control subjects, only one showed hepatic fluorescence of a porphyrin character. The control patient with a positive finding was found to have definitely increased urinary uroporphyrin excretion and probably has latent porphyria cutanea tarda. The procedure described should be useful as a screening test for hepatic cutaneous porphyria.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/22/6/704}, eprint = {https://jcp.bmj.com/content/22/6/704.full.pdf}, journal = {Journal of Clinical Pathology} }