PT  - JOURNAL ARTICLE
AU  - Hulbert, J.
TI  - Urinary tract infection and oral penicillin G
AID  - 10.1136/jcp.25.1.73
DP  - 1972 Jan 01
TA  - Journal of Clinical Pathology
PG  - 73--75
VI  - 25
IP  - 1
4099  - http://jcp.bmj.com/content/25/1/73.short
4100  - http://jcp.bmj.com/content/25/1/73.full
SO  - J Clin Pathol1972 Jan 01; 25
AB  - The urinary excretion of three oral preparations of penicillin G was measured in six subjects. After a dose of 500 mg of potassium penicillin G the mean urine level was 597 μg/ml in the first of three two-hour periods, 324 μg/ml in the second, and 40 μg/ml between the fourth and sixth hours. Of the dose, 13·4% was excreted in the urine in 24 hours. Differences among the three preparations were not significant therapeutically. Most Gram-negative urinary pathogens are sensitive to 5-50 μg of penicillin G per ml. There is a rational basis for the use of oral penicillini G to treat urinary infection due to Gram-negative bacilli.