PT - JOURNAL ARTICLE AU - R. G. Huntsman AU - G. P. T. Barclay AU - D. M. Canning AU - G. I. Yawson TI - A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia AID - 10.1136/jcp.23.9.781 DP - 1970 Dec 01 TA - Journal of Clinical Pathology PG - 781--783 VI - 23 IP - 9 4099 - http://jcp.bmj.com/content/23/9/781.short 4100 - http://jcp.bmj.com/content/23/9/781.full SO - J Clin Pathol1970 Dec 01; 23 AB - A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0ยท1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.