RT Journal Article
SR Electronic
T1 Glucose-6-phosphate dehydrogenase deficiency and chronic haemolysis in an English family
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 135
OP 139
DO 10.1136/jcp.23.2.135
VO 23
IS 2
A1 Huskisson, E. C.
A1 Murphy, B.
A1 West, Carolyn
YR 1970
UL http://jcp.bmj.com/content/23/2/135.abstract
AB Three male members of an English family with chronic haemolytic anaemia due to glucose-6-phosphate dehydrogenase deficiency are reported. The disease was symptomless in one adult, but crises, caused either by increased haemolysis or failure of marrow compensation, occurred in two children. They were typically precipitated by trivial infection. Two normal female members of the family were obligatory heterozygotes. A hitherto undescribed `slow' variant of the enzyme was identified electrophoretically.