PT - JOURNAL ARTICLE AU - M. J. Mitchinson TI - Aortic disease in idiopathic retroperitoneal and mediastinal fibrosis AID - 10.1136/jcp.25.4.287 DP - 1972 Apr 01 TA - Journal of Clinical Pathology PG - 287--293 VI - 25 IP - 4 4099 - http://jcp.bmj.com/content/25/4/287.short 4100 - http://jcp.bmj.com/content/25/4/287.full SO - J Clin Pathol1972 Apr 01; 25 AB - In three patients with idiopathic mediastinal or retroperitoneal fibrosis, postmortem sections of the aorta showed aortitis (in one case) or extrusions of atheromatous debris into the inflamed adventitia (two cases). It is suggested that damage to the aortic wall, followed by adventitial inflammation due to allergy to a component of the atherosclerotic plaque, is one way in which this disease may develop.