RT Journal Article
SR Electronic
T1 Activity of FL 1060, a new β-lactam antibiotic, against urinary tract pathogens
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 192
OP 197
DO 10.1136/jcp.27.3.192
VO 27
IS 3
A1 Greenwood, D.
A1 Brooks, H. Linton
A1 Gargan, R.
A1 O'Grady, F.
YR 1974
UL http://jcp.bmj.com/content/27/3/192.abstract
AB The effect of the new β-lactam antibiotic FL 1060 on urinary tract pathogens, of which 71 were sensitive to and 100 resistant to ampicillin, is presented here. When tested by conventional methods FL 1060 was found to be highly active against ampicillin-sensitive strains of E. coli but phenotypically resistant variants readily emerged, particularly when a large inoculum was used. Thirty-one per cent of ampicillin-resistant strains were found to be sensitive to less than 500 μg FL 1060 per ml, and in general this antibiotic was more active than ampicillin against resistant strains. In a system simulating the mechanical features of the urinary bladder the activity of FL 1060 against three sensitive strains of E. coli was found to be greater than ampicillin in conditions of low, but not high, osmolality.