PT  - JOURNAL ARTICLE
AU  - Frederick S. Southwick
AU  - David T. Durack
TI  - Chemotherapy of experimental streptococcal endocarditis
AID  - 10.1136/jcp.27.4.261
DP  - 1974 Apr 01
TA  - Journal of Clinical Pathology
PG  - 261--264
VI  - 27
IP  - 4
4099  - http://jcp.bmj.com/content/27/4/261.short
4100  - http://jcp.bmj.com/content/27/4/261.full
SO  - J Clin Pathol1974 Apr 01; 27
AB  - Bacteriostatic agents are frequently recommended as alternatives to penicillin for prophylaxis of bacterial endocarditis. To test the efficacy of this group of antimicrobials, prophylaxis of experimental streptococcal endocarditis was attempted with tetracycline. The number of streptococci colonizing the aortic valves of rabbits was not affected by inhibitory levels of tetracycline, but multiplication was checked. Streptococcis urvived in vegetations for seven days despite the continuous presence of tetracycline, and multiplied when the drug was withdrawn. It is therefore suggested that bacteriostatic agents may be valueless for prophylaxis of bacterial endocarditis.