RT Journal Article
SR Electronic
T1 Chemotherapy of experimental streptococcal endocarditis
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 261
OP 264
DO 10.1136/jcp.27.4.261
VO 27
IS 4
A1 Frederick S. Southwick
A1 David T. Durack
YR 1974
UL http://jcp.bmj.com/content/27/4/261.abstract
AB Bacteriostatic agents are frequently recommended as alternatives to penicillin for prophylaxis of bacterial endocarditis. To test the efficacy of this group of antimicrobials, prophylaxis of experimental streptococcal endocarditis was attempted with tetracycline. The number of streptococci colonizing the aortic valves of rabbits was not affected by inhibitory levels of tetracycline, but multiplication was checked. Streptococcis urvived in vegetations for seven days despite the continuous presence of tetracycline, and multiplied when the drug was withdrawn. It is therefore suggested that bacteriostatic agents may be valueless for prophylaxis of bacterial endocarditis.