RT Journal Article
SR Electronic
T1 Plasma erythropoietin assay in patients with chronic renal failure.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 875
OP 878
DO 10.1136/jcp.28.11.875
VO 28
IS 11
A1 S Davies
A1 E Glynne-Jones
A1 M Bisson
A1 P Bisson
YR 1975
UL http://jcp.bmj.com/content/28/11/875.abstract
AB Using the post-hypoxic mouse method of assay, values for erythropoietin in the plasma of patients with chronic renal failure were equal to, or greater than, normal values. Results suggest that the source of erythropoietin may be primarily extrarenal. Normal renal tissue, provided in the assay by the intact mouse, is required for activation of the hormone. There still remains to be explained the enhanced erythropoietic response to haemorrhage or hypoxia that can occur in anephric man.