PT - JOURNAL ARTICLE AU - Henshaw, L A AU - Tizzard, J L AU - Booth, K AU - Beard, M E TI - Haemoglobin A2 levels in vitamin B12 and folate deficiency. AID - 10.1136/jcp.31.10.960 DP - 1978 Oct 01 TA - Journal of Clinical Pathology PG - 960--962 VI - 31 IP - 10 4099 - http://jcp.bmj.com/content/31/10/960.short 4100 - http://jcp.bmj.com/content/31/10/960.full SO - J Clin Pathol1978 Oct 01; 31 AB - Haemoglobin A2 levels were measured in 50 patients with vitamin B12 deficiency, 50 patients with folate deficiency, and six patients with combined deficiencies of these vitamins. All were normal except for three patients with vitamin B12 deficiency, who had a slightly elevated Hb A2 level; this fell to normal after vitamin B12 therapy. It is concluded that haemoglobin A2 levels are usually normal in vitamin B12 or folate deficiency. However, raised levels of haemoglobin A2 may be found, but these are not as high as is found in beta thalassaemia trait and should not cause difficutly in diagnosis.