TY - JOUR T1 - Human endodermal sinus tumour in nude mice and its markers for diagnosis and management. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 693 LP - 699 DO - 10.1136/jcp.32.7.693 VL - 32 IS - 7 AU - T Takeuchi AU - M Nakayasu AU - S Hirohashi AU - T Kameya AU - M Kaneko AU - K Yokomori AU - Y Tsuchida Y1 - 1979/07/01 UR - http://jcp.bmj.com/content/32/7/693.abstract N2 - Two human endodermal sinus tumours (yolk sac tumours) were transplanted successfully into nude mice. The transplanted tumours maintained not only morphological characters, such as Schiller-Duval bodies, but also the ability to synthesise alpha-fetoprotein, lactic dehydrogenase 1, liver and bone type alkaline phosphatase, and some human serum proteins. Since these tumours produced lactic dehydrogenase 1 but not the other four isozymes of lactic dehydrogenase, this isozyme, like alpha-fetoprotein, seems to be a good marker for the diagnosis and management of cases of endodermal sinus tumour. One of the two tumours produced another fetal antigen or carcinoembryonic antigen in addition to alpha-fetoprotein. These two endodermal sinus tumours, with their various markers in nude mice, will be useful in studies on diagnostic markers. ER -