PT  - JOURNAL ARTICLE
AU  - Takeuchi, T
AU  - Nakayasu, M
AU  - Hirohashi, S
AU  - Kameya, T
AU  - Kaneko, M
AU  - Yokomori, K
AU  - Tsuchida, Y
TI  - Human endodermal sinus tumour in nude mice and its markers for diagnosis and management.
AID  - 10.1136/jcp.32.7.693
DP  - 1979 Jul 01
TA  - Journal of Clinical Pathology
PG  - 693--699
VI  - 32
IP  - 7
4099  - http://jcp.bmj.com/content/32/7/693.short
4100  - http://jcp.bmj.com/content/32/7/693.full
SO  - J Clin Pathol1979 Jul 01; 32
AB  - Two human endodermal sinus tumours (yolk sac tumours) were transplanted successfully into nude mice. The transplanted tumours maintained not only morphological characters, such as Schiller-Duval bodies, but also the ability to synthesise alpha-fetoprotein, lactic dehydrogenase 1, liver and bone type alkaline phosphatase, and some human serum proteins. Since these tumours produced lactic dehydrogenase 1 but not the other four isozymes of lactic dehydrogenase, this isozyme, like alpha-fetoprotein, seems to be a good marker for the diagnosis and management of cases of endodermal sinus tumour. One of the two tumours produced another fetal antigen or carcinoembryonic antigen in addition to alpha-fetoprotein. These two endodermal sinus tumours, with their various markers in nude mice, will be useful in studies on diagnostic markers.