RT Journal Article SR Electronic T1 Human endodermal sinus tumour in nude mice and its markers for diagnosis and management. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 693 OP 699 DO 10.1136/jcp.32.7.693 VO 32 IS 7 A1 Takeuchi, T A1 Nakayasu, M A1 Hirohashi, S A1 Kameya, T A1 Kaneko, M A1 Yokomori, K A1 Tsuchida, Y YR 1979 UL http://jcp.bmj.com/content/32/7/693.abstract AB Two human endodermal sinus tumours (yolk sac tumours) were transplanted successfully into nude mice. The transplanted tumours maintained not only morphological characters, such as Schiller-Duval bodies, but also the ability to synthesise alpha-fetoprotein, lactic dehydrogenase 1, liver and bone type alkaline phosphatase, and some human serum proteins. Since these tumours produced lactic dehydrogenase 1 but not the other four isozymes of lactic dehydrogenase, this isozyme, like alpha-fetoprotein, seems to be a good marker for the diagnosis and management of cases of endodermal sinus tumour. One of the two tumours produced another fetal antigen or carcinoembryonic antigen in addition to alpha-fetoprotein. These two endodermal sinus tumours, with their various markers in nude mice, will be useful in studies on diagnostic markers.