PT  - JOURNAL ARTICLE
AU  - M M Drummond
AU  - G D Lowe
AU  - J J Belch
AU  - J C Barbenel
AU  - C D Forbes
TI  - An assessment of red cell deformability using a simple filtration method.
AID  - 10.1136/jcp.33.4.373
DP  - 1980 Apr 01
TA  - Journal of Clinical Pathology
PG  - 373--376
VI  - 33
IP  - 4
4099  - http://jcp.bmj.com/content/33/4/373.short
4100  - http://jcp.bmj.com/content/33/4/373.full
SO  - J Clin Pathol1980 Apr 01; 33
AB  - We assessed the simple method of measuring red cell deformability described by Reid et al. The technique was found to be reproducible. The validity of the method as a measure of red cell deformation was confirmed by (a) marked reduction of the deformability index after fixation of red cells with glutaraldehyde, and (b) an inverse correlation of deformability index with high-shear blood viscosity (r = 0.4; P < 0.001). There was no correlation of deformability index with low-shear blood viscosity, plasma viscosity, fibrinogen, or the white cell count. In normal subjects, deformability index was similar in males and females, and in smokers and non-smokers. Patients with acute myocardial infarction, or intermittent claudication, had reduced deformability compared to controls (P < 0.01).