PT  - JOURNAL ARTICLE
AU  - A J Dixon
AU  - J Burns
AU  - M S Dunnill
AU  - J O McGee
TI  - Distribution of fibronectin in normal and diseased human kidneys.
AID  - 10.1136/jcp.33.11.1021
DP  - 1980 Nov 01
TA  - Journal of Clinical Pathology
PG  - 1021--1028
VI  - 33
IP  - 11
4099  - http://jcp.bmj.com/content/33/11/1021.short
4100  - http://jcp.bmj.com/content/33/11/1021.full
SO  - J Clin Pathol1980 Nov 01; 33
AB  - The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material. Biopsies were obtained from normal human kidneys and from patients with a variety of glomerular disorders. In normal glomeruli, fibronectin was present in Bowman's capsule, in the mesangium, and outlining peripheral capillary loops. A significant increase in fibronectin was observed in most types of glomerulopathy with a distribution closely related to the histopathological diagnosis. Fibronectin was diminished or absent in segmental scars, old diabetic nodules, and hyalinised glomeruli.