RT Journal Article
SR Electronic
T1 Angiofollicular and plasmacytic polyadenopathy: a pseudotumourous syndrome with dysimmunity.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1068
OP 1076
DO 10.1136/jcp.33.11.1068
VO 33
IS 11
A1 J Diebold
A1 M Tulliez
A1 A Bernadou
A1 J Audouin
A1 G Tricot
A1 M Reynes
A1 G Bilski-Pasquier
YR 1980
UL http://jcp.bmj.com/content/33/11/1068.abstract
AB Two cases are reported of an apparently distinct type of immune disorder. Beginning with mild anaemia and widespread massive lymphadenopathy, the disease progressed to a fatal autoimmune type haemolytic anaemia. Serum investigation showed polyclonal hypergamma-globulinaemia and some autoantibodies. Repeat lymph node biopsies in each case showed hyperplasia within B lymphocyte territory (follicular hyperplasia and polyclonal plasmacytosis with IgG predominance) and atrophy of T dependent areas. Dilatation of lymph sinuses, vascular proliferation, and sclerosis were striking features. This appears to be a new entity, and reasons are given for separating this disease from other pseudotumourous lymph node disorders associated with dysimmunity.