PT  - JOURNAL ARTICLE
AU  - J M Sloan
AU  - K D Buchanan
AU  - R J McFarland
AU  - P Titterington
AU  - J C Sandford
TI  - A histological study of the effect of chronic gastritis on gastrin cell distribution in the human stomach.
AID  - 10.1136/jcp.32.3.201
DP  - 1979 Mar 01
TA  - Journal of Clinical Pathology
PG  - 201--207
VI  - 32
IP  - 3
4099  - http://jcp.bmj.com/content/32/3/201.short
4100  - http://jcp.bmj.com/content/32/3/201.full
SO  - J Clin Pathol1979 Mar 01; 32
AB  - To determine the effect of varying degrees of gastritis on the distribution of immuno-reactive gastrin cells 38 partial gastrectomy specimens have been studied. Routinely stained histological sections of mucosa were compared with serial and adjacent sections stained by specific immunohistochemistry using peroxidase and fluorescent techniques. While chronic superficial gastritis had no obvious effect, mild atrophic gastritis was associated with an uneven distribution of gastrin cells which became more marked with increasing severity of gastritis. In the region of intestinal metaplasia gastrin cells were almost totally absent. Small numbers of gastrin cells were found within areas of pseudopyloric metaplasia in the fundus, a region where those cells are not normally seen. Similarly, gastrin cells were detected within regenerative gastric polypi in both antrum and fundus.