PT  - JOURNAL ARTICLE
AU  - J Gordon
AU  - J L Smith
TI  - Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis.
AID  - 10.1136/jcp.33.6.539
DP  - 1980 Jun 01
TA  - Journal of Clinical Pathology
PG  - 539--554
VI  - 33
IP  - 6
4099  - http://jcp.bmj.com/content/33/6/539.short
4100  - http://jcp.bmj.com/content/33/6/539.full
SO  - J Clin Pathol1980 Jun 01; 33
AB  - Tumour populations from two B cell neoplasms were investigated for their capacity to synthesise immunoglobulin in vitro. Neoplastic cells from a patient with chronic lymphocytic leukaemia and an IgG lambda paraproteinaemia co-expressed surface IgG lambda and IgM lambda and synthesised both IgG lambda and IgM lambda in short-term culture. In the second patient with non-Hodgkin's lymphoma, the neoplastic cells expressed surface IgM lambda but synthesised both IgM lambda and IgG lambda in vitro. The findings are discussed in terms of a model for the clonal switch from IgM to IgG synthesis.