RT Journal Article
SR Electronic
T1 Zinc acetate as a precipitant of unstable haemoglobins.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 796
OP 799
DO 10.1136/jcp.34.7.796
VO 34
IS 7
A1 Carrell, R W
A1 Lehmann, H
YR 1981
UL http://jcp.bmj.com/content/34/7/796.abstract
AB Whereas the addition of four moles of zinc acetate to one of normal human haemoglobin at pH 7.4 results in a clear solution, addition to unstable haemoglobin results in precipitate formation. Within certain limits no false-positive results are obtained with methaemoglobin, and with fetal haemoglobin. With excess zinc, normal haemoglobin also precipitates, but this process is reversible and can be used for a rapid concentration of dilute solutions of normal haemoglobin.