RT Journal Article
SR Electronic
T1 Mouse red cell rosette formation and the colchicine sensitivity test: relative usefulness in the differential diagnosis of chronic lymphocytic leukaemia and B lymphocytic lymphoma.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 376
OP 379
DO 10.1136/jcp.35.4.376
VO 35
IS 4
A1 P J Sugden
A1 J S Lilleyman
YR 1982
UL http://jcp.bmj.com/content/35/4/376.abstract
AB Mouse erythrocyte (M) rosette formation and colchicine sensitivity were compared for their ability to differentiate chronic lymphocytic leukaemia (CLL) from B cell non-Hodgkin's lymphoma (NHL) with overspill. Twenty-two cases of CLL and eight of NHL were studied along with 31 normal adults. Results from the patients in both tests differed significantly from the controls but colchicine sensitivity failed to differentiate them further. M Rosettes, on the other hand, while increased in some patients with NHL were, without overlap, much more numerous in those with CLL, and clearly distinguished the two conditions. A significant autolymphocytotoxic effect of plasma from both study groups was also noted which was not found in the controls.