TY - JOUR T1 - Counterimmunoelectrophoresis in the serodiagnosis of Legionnaires' disease. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 466 LP - 470 DO - 10.1136/jcp.36.4.466 VL - 36 IS - 4 AU - M Holliday Y1 - 1983/04/01 UR - http://jcp.bmj.com/content/36/4/466.abstract N2 - Counterimmunoelectrophoresis (CIE) was found to be a rapid, specific method for detecting circulating antibodies to Legionella pneumophila, using a simple ultrasonically disrupted antigen. The diagnostic specificity of the technique was 93% and the diagnostic sensitivity was 86.3%. Both IgM and IgG classes of antibody can be detected. There is some cross-reactivity between serogroup 1 and serogroup 6 but none between serogroup 1 and serogroups 3, 4, and 5. It is suggested that CIE may provide a simple, reproducible screening test for Legionnaires' disease. ER -