PT  - JOURNAL ARTICLE
AU  - D Junglee
AU  - R De Albarran
AU  - A Katrak
AU  - D B Freedman
AU  - A G Beckett
AU  - P Dandona
TI  - Low pancreatic lipase in insulin-dependent diabetics.
AID  - 10.1136/jcp.36.2.200
DP  - 1983 Feb 01
TA  - Journal of Clinical Pathology
PG  - 200--202
VI  - 36
IP  - 2
4099  - http://jcp.bmj.com/content/36/2/200.short
4100  - http://jcp.bmj.com/content/36/2/200.full
SO  - J Clin Pathol1983 Feb 01; 36
AB  - Serum samples obtained from 20 insulin-dependent diabetics (IDD), 23 non-insulin-dependent diabetics (NIDD) and 30 controls were assayed for their pancreatic lipase activity, immunoreactive trypsin concentration and glycosylated haemoglobin (HbA1) respectively. The distribution of serum pancreatic lipase activity in normal subjects and diabetics was nonparametric. The median serum lipase activity in IDDs (86 U/l) was significantly lower that that in controls (131 U/l, p less than 0.002) and NIDDs (126 U/l, p less than 0.001). There was a significant correlation between serum pancreatic lipase activity and serum IRT concentration (r = 0.65, p less than 0.001). Neither pancreatic lipase activity nor IRT was related to HbA1 concentrations. These data show for the first time that serum pancreatic lipase activity is diminished in IDDs.