@article {Colley203, author = {C M Colley and A Fleck and A W Goode and B R Muller and M A Myers}, title = {Early time course of the acute phase protein response in man.}, volume = {36}, number = {2}, pages = {203--207}, year = {1983}, doi = {10.1136/jcp.36.2.203}, publisher = {BMJ Publishing Group}, abstract = {The rate at which the acute phase protein response occurred after both major and minor surgery was explored. Increases in the plasma concentration of C-reactive protein (CRP), alpha-1-acid glycoprotein (alpha 1 AG) and fibrinogen were not detected until 6-8 h after the initial incision. The peak concentration of CRP occurred at 48 h and that of fibrinogen at 96 h; alpha 1 AG concentrations rose rapidly until 48 h followed by little change until about 120 h. Although there was widespread variation in the concentrations of individual proteins in patients, severity of injury did not seem to have a significant effect on the time course of the change. Plasma cortisol concentration and the total white blood cell count (WBC) reached their peaks before the acute phase proteins, cortisol at 6 h and WBC at 12 h.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/36/2/203}, eprint = {https://jcp.bmj.com/content/36/2/203.full.pdf}, journal = {Journal of Clinical Pathology} }