RT Journal Article
SR Electronic
T1 Uptake of ciprofloxacin by macrophages.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 442
OP 444
DO 10.1136/jcp.38.4.442
VO 38
IS 4
A1 C S Easmon
A1 J P Crane
YR 1985
UL http://jcp.bmj.com/content/38/4/442.abstract
AB Ciprofloxacin was concentrated within mouse peritoneal macrophages to between two and three times extracellular values. Uptake was rapid, occurred equally well with dead cells, and was not affected by lowering the pH or by prior ingestion of Staphylococcus aureus. Intracellular staphylococci were killed by extracellular concentrations of ciprofloxacin as low as 0.5 mg/l.