PT  - JOURNAL ARTICLE
AU  - R A Williams
AU  - J Rode
AU  - A P Dhillon
AU  - L R Jarvis
AU  - J M Skinner
AU  - O Jamal
TI  - Measuring S100 protein and neurone specific enolase in melanocytic tumours using video image analysis.
AID  - 10.1136/jcp.39.10.1096
DP  - 1986 Oct 01
TA  - Journal of Clinical Pathology
PG  - 1096--1098
VI  - 39
IP  - 10
4099  - http://jcp.bmj.com/content/39/10/1096.short
4100  - http://jcp.bmj.com/content/39/10/1096.full
SO  - J Clin Pathol1986 Oct 01; 39
AB  - Using a computed video image analysis system, the staining intensity for both neurone specific enolase (NSE) and S100 protein was measured in sections from 19 malignant melanomas and 16 benign melanocytic lesions. The results of this study confirm previous reports that NSE and S100 protein are useful markers for malignant melanoma. NSE staining intensity in the cases of malignant melanoma was significantly higher than that in benign naevi (p = 0.011). Intensity of staining for S100 protein was not significantly higher in the malignant melanomas. There was, however, a significant S100 gradient when comparing superficial and deep intradermal portions of these tumours (p = 0.003). This feature was not seen in benign naevi. The greatest intensity of S100 protein staining was found in the deeper portions of the malignant melanomas. This gradient difference was not seen with staining for NSE. Although it seems that the overall intensity of staining for NSE is more effective in differentiating between benign and malignant lesions, the difference in staining intensity between the superficial and deep portions of the tumour may be the better indicator of adverse behaviour in lesions in which the diagnosis of malignancy is uncertain.