%0 Journal Article %A N T O'Connor %A J A Crick %A J S Wainscoat %A K C Gatter %A H Stein %A B Falini %A D Y Mason %T Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy. %D 1986 %R 10.1136/jcp.39.11.1229 %J Journal of Clinical Pathology %P 1229-1232 %V 39 %N 11 %X The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma. %U https://jcp.bmj.com/content/jclinpath/39/11/1229.full.pdf