TY - JOUR T1 - Increased alpha:non-alpha globin chain synthesis ratios in myelodysplastic syndromes and myeloid leukaemia. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 1233 LP - 1235 DO - 10.1136/jcp.39.11.1233 VL - 39 IS - 11 AU - R E Peters AU - A May AU - A Jacobs Y1 - 1986/11/01 UR - http://jcp.bmj.com/content/39/11/1233.abstract N2 - Globin chain synthesis ratios (alpha:beta + gamma) in leucocyte free reticulocytes from six of 11 patients with various myelodysplastic syndromes were high, ranging from 1.28 to 2.43. High ratios were also found for reticulocytes from two of four patients with acute myeloblastic leukaemia. Of the eight cases in which high ratios were found, seven were in patients who were either undergoing leukaemic transformation or who had already transformed. The reason for these findings is not known, but an understanding of the mechanism may give us further insight into the process of leukaemic transformation. ER -