TY - JOUR T1 - Granulocyte and monocyte surface membrane markers in the myelodysplastic syndromes. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 301 LP - 304 DO - 10.1136/jcp.38.3.301 VL - 38 IS - 3 AU - R E Clark AU - T G Hoy AU - A Jacobs Y1 - 1985/03/01 UR - http://jcp.bmj.com/content/38/3/301.abstract N2 - The expression of lineage specific surface antigens on granulocytes and monocytes was quantitated using monoclonal antibodies in 16 healthy adults and 21 patients with myelodysplastic syndromes. In nine of 19 patients the granulocytes showed a decrease in myeloid or an increase in monocyte antigen expression or both. In 11 of 19 patients the monocytes showed a decreased expression of monocyte antigens or an increase in myeloid antigens or both. The data suggest that in the myelodysplastic syndromes the granulocyte-macrophage progenitors do not develop along two divergent lines but differentiate with the emergence of dual characteristics. ER -