PT - JOURNAL ARTICLE AU - J E Neild AU - P G Byfield AU - M R Lalloz AU - D Tait AU - J H Marigold AU - D N Croft AU - B M Slavin TI - Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation. AID - 10.1136/jcp.38.3.327 DP - 1985 Mar 01 TA - Journal of Clinical Pathology PG - 327--330 VI - 38 IP - 3 4099 - http://jcp.bmj.com/content/38/3/327.short 4100 - http://jcp.bmj.com/content/38/3/327.full SO - J Clin Pathol1985 Mar 01; 38 AB - A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodothyronine concentrations were normal. Problems encountered in the recognition of this thyroxine binding protein disorder are discussed. Clinicians and clinical biochemists should be aware of these pitfalls and thus avoid further incorrect treatment on the basis of biochemical findings, even though free hormone estimations are now becoming readily available.