RT Journal Article
SR Electronic
T1 Prostatic adenocarcinoma evolving into carcinoid: selective effect of hormonal treatment?
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 750
OP 756
DO 10.1136/jcp.39.7.750
VO 39
IS 7
A1 M Stratton
A1 D J Evans
A1 I A Lampert
YR 1986
UL http://jcp.bmj.com/content/39/7/750.abstract
AB Two patients, aged 72 and 65 years, each underwent two prostatic resections spaced four and two years apart, respectively. In both cases the earlier procedure showed widespread adenocarcinoma with only occasional endocrine cells, while tissue from the later operations showed prostatic carcinoids. It is suggested that the conventional adenocarcinomas were sensitive to hormonal manipulations used in treatment, but that the originally sparse carcinoid components were resistant to this form of treatment and hence became the predominant tumours. These findings imply that endocrine differentiation in prostatic carcinoma leads to lack of sex steroid sensitivity.