PT  - JOURNAL ARTICLE
AU  - S Abe
AU  - Y Amagasaki
AU  - S Iyori
AU  - K Konishi
AU  - E Kato
AU  - H Sakaguchi
AU  - K Shimoyama
TI  - Thin basement membrane syndrome in adults.
AID  - 10.1136/jcp.40.3.318
DP  - 1987 Mar 01
TA  - Journal of Clinical Pathology
PG  - 318--322
VI  - 40
IP  - 3
4099  - http://jcp.bmj.com/content/40/3/318.short
4100  - http://jcp.bmj.com/content/40/3/318.full
SO  - J Clin Pathol1987 Mar 01; 40
AB  - Eight (two men, six women) cases of adult thin basement membrane syndrome were studied to clarify the clinicopathological characteristics of the disease. The average age at the time of biopsy was 40 years. All the patients had persistent microscopic haematuria, normal renal function, and normal blood pressure, with the exception of one who was hypotensive. Most of them had persistent or transient proteinuria. Renal symptoms were found in four families, although no relative had Alport's syndrome. Renal biopsy findings observed by light and immunofluorescence microscopy did not indicate any important abnormalities, but extensive diffuse thinning of the glomerular basement membrane, ranging from 153 to 213 nm, was a constant finding by electron microscopy. All the patients retained stable renal function at the time of final follow up, indicating a benign prognosis of the syndrome.