PT  - JOURNAL ARTICLE
AU  - Wilkie, A O
AU  - Kitchen, C
AU  - Oakhill, A
AU  - Howell, R T
AU  - Berry, P J
TI  - Dicentric chromosome in the bone marrow of a child with megakaryoblastic leukaemia and Down's syndrome.
AID  - 10.1136/jcp.41.4.378
DP  - 1988 Apr 01
TA  - Journal of Clinical Pathology
PG  - 378--380
VI  - 41
IP  - 4
4099  - http://jcp.bmj.com/content/41/4/378.short
4100  - http://jcp.bmj.com/content/41/4/378.full
SO  - J Clin Pathol1988 Apr 01; 41
AB  - A two year old girl with Down's syndrome (constitutional karyotype: 47 + 21), presenting with pancytopenia, developed acute megakaryoblastic leukaemia (AMKL). Her bone marrow contained an abnormal clone with a novel dicentric chromosome derived from chromosomes 5 and 7 (karyotype 46, XX, -5, -7, +dic (5;7) (p 13; p 11.2), +21. This case provides further evidence for a connection between chromosome 21 and this unusual form of childhood leukaemia, and raises questions about the loss of short arm material from chromosomes 5 and 7 compared with the more usual monosomy or long arm loss.