RT Journal Article
SR Electronic
T1 Dicentric chromosome in the bone marrow of a child with megakaryoblastic leukaemia and Down's syndrome.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 378
OP 380
DO 10.1136/jcp.41.4.378
VO 41
IS 4
A1 Wilkie, A O
A1 Kitchen, C
A1 Oakhill, A
A1 Howell, R T
A1 Berry, P J
YR 1988
UL http://jcp.bmj.com/content/41/4/378.abstract
AB A two year old girl with Down's syndrome (constitutional karyotype: 47 + 21), presenting with pancytopenia, developed acute megakaryoblastic leukaemia (AMKL). Her bone marrow contained an abnormal clone with a novel dicentric chromosome derived from chromosomes 5 and 7 (karyotype 46, XX, -5, -7, +dic (5;7) (p 13; p 11.2), +21. This case provides further evidence for a connection between chromosome 21 and this unusual form of childhood leukaemia, and raises questions about the loss of short arm material from chromosomes 5 and 7 compared with the more usual monosomy or long arm loss.