@article {Hunt712, author = {B J Hunt and P Korsah and S Eaton and M Brozovic}, title = {Creatine kinase activity in sickle cell disease.}, volume = {42}, number = {7}, pages = {712--715}, year = {1989}, doi = {10.1136/jcp.42.7.712}, publisher = {BMJ Publishing Group}, abstract = {Creatine kinase activity was measured in 28 patients in the steady state of sickle cell disease and ranged from 4-45 IU/l, comparable with that found in healthy adult caucasians. Creatine kinase activity was also measured in 14 patients admitted consecutively for the treatment of vaso-occlusive sickle cell crises. Creatine kinase activity remained within the normal range in eight of these 14 patients throughout their admission; none had muscle pain or a chest syndrome. In the remaining six, three with muscle pain and three with a chest syndrome, increased activity was found on one or more days. A further 17 patients with vaso-occlusive sickle cell crises, associated with muscle pain, were studied. Creatine kinase activity was significantly raised in all 17, the mean creatine kinase activity for men was 578.8 IU/l and 210.6 IU/l for women, with the highest values (up to 1790 IU/l) found in those who had exercised before admission. Measurement of creatine kinase activity may therefore be a useful marker of muscle perturbation due to sickling.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/42/7/712}, eprint = {https://jcp.bmj.com/content/42/7/712.full.pdf}, journal = {Journal of Clinical Pathology} }