RT Journal Article
SR Electronic
T1 Prognostic value of prostaglandin F2 alpha concentrations in breast carcinoma.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1046
OP 1048
DO 10.1136/jcp.42.10.1046
VO 42
IS 10
A1 P A van Dam
A1 I B Vergote
A1 G M Laekeman
A1 G H Keersmaeckers
A1 F L Uyttenbroeck
A1 A G Herman
YR 1989
UL http://jcp.bmj.com/content/42/10/1046.abstract
AB Prostaglandin F2 alpha (PGF2 alpha) concentrations were measured by radioimmunoassay in homogenised primary tumours from 57 patients with breast cancer. These patients were followed up from 60 to 78 months (median 63 months) after surgery and PGF2 alpha concentrations were related prospectively to metastatic spread and survival. The amounts of PGF2 alpha varied greatly in the different tumours (range 0-90 ng/mg protein), but no significant association was found between PGF2 alpha concentrations and disease free survival, time of relapse, site of recurrence, or overall survival. It therefore seems unlikely that measurement of PGF2 alpha in breast carcinoma is important in the prognosis of the disease.