RT Journal Article
SR Electronic
T1 Differentiation between Bernard-Soulier syndrome and immune thrombocytopenia by immunostaining of peripheral blood.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1296
OP 1297
DO 10.1136/jcp.42.12.1296
VO 42
IS 12
A1 L O Poulsen
A1 P Johansen
A1 M K Jensen
A1 L Freund
YR 1989
UL http://jcp.bmj.com/content/42/12/1296.abstract
AB Peripheral blood smears from seven patients with Bernard-Soulier syndrome were examined by an immunocytochemical staining procedure using a monoclonal antibody specific for platelet glycoprotein Ib. No platelet staining was observed except for very slight staining of the large sized platelets from one of the patients. Application of the assay to blood smears from 12 patients with immune thrombocytopenia showed that their peripheral platelets stained normally, so the assay can be used to differentiate between immune thrombocytopenia and Bernard-Soulier syndrome and to confirm a diagnosis of the syndrome.