RT Journal Article
SR Electronic
T1 Familial occurrence of the antiphospholipid syndrome.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 495
OP 497
DO 10.1136/jcp.42.5.495
VO 42
IS 5
A1 Matthey, F
A1 Walshe, K
A1 Mackie, I J
A1 Machin, S J
YR 1989
UL http://jcp.bmj.com/content/42/5/495.abstract
AB In a family of four the whole spectrum of antiphospholipid and associated antibodies was present but without evidence of connective tissue disease. All four members had anticardiolipin antibodies; two had a confirmed lupus anticoagulant. Thrombocytopenia was severe in one and associated with a high titre of antiplatelet antibody, while another member was found to have a positive antiglobulin test. One member also had a low protein C concentration while two had decreased concentration of protein S. Factors that predispose to these antibodies may be environmental as well as genetic. In view of the well known association of spontaneous thrombotic events with some of these antibodies the prognosis for the family members must be guarded.