RT Journal Article
SR Electronic
T1 Observer variability in histopathological reporting of cervical biopsy specimens.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 231
OP 238
DO 10.1136/jcp.42.3.231
VO 42
IS 3
A1 A J Robertson
A1 J M Anderson
A1 J S Beck
A1 R A Burnett
A1 S R Howatson
A1 F D Lee
A1 A M Lessells
A1 K M McLaren
A1 S M Moss
A1 J G Simpson
YR 1989
UL http://jcp.bmj.com/content/42/3/231.abstract
AB Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accurately between the lesser grades of CIN. It is recommended that the classification be changed to low grade (present CIN 1 and 2) and high grade (present CIN 3) categories alone. There was very poor agreement in the identification of cellular changes associated with human papilloma virus (HPV) infection.