TY - JOUR T1 - Rapid diagnosis of whooping cough using monoclonal antibody. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 573 LP - 575 DO - 10.1136/jcp.41.5.573 VL - 41 IS - 5 AU - P C Boreland AU - S H Gillespie AU - L A Ashworth Y1 - 1988/05/01 UR - http://jcp.bmj.com/content/41/5/573.abstract N2 - A counterimmunoelectrophoresis (CIE) method for antigen detection using monoclonal antibody was assessed for its ability to aid in the rapid diagnosis of Bordetella pertussis in 59 patients. A positive diagnosis from a combination of results from tests of serum and urine was obtained in 51 (87%) of cases. For sera, CIE had a sensitivity of 85% and a specificity of 94%; for urine samples the sensitivity was 81% and a specificity of 100%. Antigen detection by CIE is simple to perform and yields results on the same day, thus allowing treatment to begin at an early stage. ER -