PT - JOURNAL ARTICLE AU - H Crocker AU - M D Shephard AU - G H White TI - Evaluation of an enzymatic method for determining creatinine in plasma. AID - 10.1136/jcp.41.5.576 DP - 1988 May 01 TA - Journal of Clinical Pathology PG - 576--581 VI - 41 IP - 5 4099 - http://jcp.bmj.com/content/41/5/576.short 4100 - http://jcp.bmj.com/content/41/5/576.full SO - J Clin Pathol1988 May 01; 41 AB - An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffé-based method. The enzymatic method exhibited several advantages over Jaffé-based methods--namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.