RT Journal Article SR Electronic T1 Evaluation of an enzymatic method for determining creatinine in plasma. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 576 OP 581 DO 10.1136/jcp.41.5.576 VO 41 IS 5 A1 H Crocker A1 M D Shephard A1 G H White YR 1988 UL http://jcp.bmj.com/content/41/5/576.abstract AB An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffé-based method. The enzymatic method exhibited several advantages over Jaffé-based methods--namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.