RT Journal Article SR Electronic T1 Clinical importance of squamous metaplasia in invasive transitional cell carcinoma of the bladder. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 250 OP 253 DO 10.1136/jcp.42.3.250 VO 42 IS 3 A1 J E Martin A1 B J Jenkins A1 R J Zuk A1 J P Blandy A1 S I Baithun YR 1989 UL http://jcp.bmj.com/content/42/3/250.abstract AB One hundred cases of transitional cell carcinoma of the bladder were studied to determine whether squamous metaplasia and other histological features within the bladder can be of value in predicting outcome of treatment with radiotherapy. Sixty cases showed the changes of squamous metaplasia, and of this group 46 (78%) failed to respond to radiotherapy. A significant response rate of 90% was seen in the 40 tumours without squamous metaplasia. It is concluded that transitional cell carcinomas of the bladder showing squamous metaplasia are mainly resistant to radiotherapy and alternative treatment methods should be sought.