RT Journal Article
SR Electronic
T1 Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 17
OP 21
DO 10.1136/jcp.43.1.17
VO 43
IS 1
A1 A J Robertson
A1 J S Beck
A1 R A Burnett
A1 S R Howatson
A1 F D Lee
A1 A M Lessells
A1 K M McLaren
A1 S M Moss
A1 J G Simpson
A1 G D Smith
YR 1990
UL http://jcp.bmj.com/content/43/1/17.abstract
AB Sections from 90 urinary bladder biopsy specimens were examined by 11 consultant histopathologists with varying experience to determine the appropriateness of existing pathology terminology. Analysis with kappa statistics showed fair to good agreement in the grading and staging of transitional cell carcinoma. There was also reasonable agreement in the diagnosis of high grade dysplasia in random biopsy specimens from the urothelium adjacent to the neoplasm, but very poor agreement for lesser degrees of dysplasia. It is concluded that the present classification of bladder carcinomata is reliable and that pathologists can determine stage with a high degree of reproducibility and grade with a fair degree of reproducibility.