PT  - JOURNAL ARTICLE
AU  - Lai, A P
AU  - Wierzbicki, A S
AU  - Norman, P M
TI  - Immunocytological diagnosis of primary cerebral non-Hodgkin's lymphoma.
AID  - 10.1136/jcp.44.3.251
DP  - 1991 Mar 01
TA  - Journal of Clinical Pathology
PG  - 251--253
VI  - 44
IP  - 3
4099  - http://jcp.bmj.com/content/44/3/251.short
4100  - http://jcp.bmj.com/content/44/3/251.full
SO  - J Clin Pathol1991 Mar 01; 44
AB  - Four men with primary cerebral non-Hodgkin's lymphoma diagnosed by immunocytological analysis of cerebrospinal fluid (CSF) presented with cranial nerve palsies. All had CSF lymphocytoses and low CSF glucose. The cell phenotypes were two T cell tumours, one B cell, and one null. A review of 13 previously recorded cases of immunocytologically diagnosed CNS non-Hodgkin's lymphoma showed that there were 10 B cell, two T cell, and one null tumour. Overall (17 cases) the cell phenotype distribution was 65% B cell, 24% T cell, and 11% null. High CSF lymphocyte counts were found in 94%, proteinosis in 85%, and low CSF glucose in 87%. In contrast to the B cell tumours, all of the T cell tumours were diagnosed by CSF cytology before being visualised radiologically. It is suggested that all CSF lymphocytes (greater than 5 x 10(6)/ml) should be immunohistochemically typed to permit earlier diagnosis of CNS non-Hodgkin's lymphoma.