PT  - JOURNAL ARTICLE
AU  - S A Aparicio
AU  - S Mojiminiyi
AU  - J D Kay
AU  - B J Shepstone
AU  - K de Ceulaer
AU  - G R Serjeant
TI  - Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 51Cr-EDTA clearance, creatinine clearance, serum creatinine and beta 2 microglobulin.
AID  - 10.1136/jcp.43.5.370
DP  - 1990 May 01
TA  - Journal of Clinical Pathology
PG  - 370--372
VI  - 43
IP  - 5
4099  - http://jcp.bmj.com/content/43/5/370.short
4100  - http://jcp.bmj.com/content/43/5/370.full
SO  - J Clin Pathol1990 May 01; 43
AB  - Glomerular filtration rates (GFR) were measured with 51Cr-EDTA in 38 patients (aged 40-75 years) with homozygous sickle cell disease and compared with serum beta 2 microglobulin concentrations in 38 patients and with creatinine clearance in 21 patients. GFR estimated with 51Cr-EDTA was closely correlated with single serum creatinine measurements and the inverse of serum beta 2 microglobulin. Creatinine clearance was also found to be correlated, but values were, on average, 32% below those obtained by the 51Cr-EDTA method, and this difference was significant. It is concluded that measurements of beta 2 microglobulin, single serum creatinine, and creatinine clearance are valuable indicators of GFR in homozygous sickle cell disease. Measurement of beta 2 microglobulin was a useful and reliable method of estimating GFR from single plasma measurements and is therefore a useful means of screening the population.