PT - JOURNAL ARTICLE AU - P Patel AU - S O'Rahilly AU - V Buckle AU - Y Nakamura AU - R C Turner AU - J S Wainscoat TI - Chromosome 11 allele loss in sporadic insulinoma. AID - 10.1136/jcp.43.5.377 DP - 1990 May 01 TA - Journal of Clinical Pathology PG - 377--378 VI - 43 IP - 5 4099 - http://jcp.bmj.com/content/43/5/377.short 4100 - http://jcp.bmj.com/content/43/5/377.full SO - J Clin Pathol1990 May 01; 43 AB - DNA was extracted from tissue samples of three unrelated cases of insulinoma. Chromosome 11 allele loss was investigated using several chromosome 11 specific probes which detect restriction fragment length polymorphisms. In one case, which proved informative for many of the chromosome 11 markers, allele loss was shown on both 11p and 11q. This finding is of considerable interest as the allele loss closely corresponds to that recently reported in insulinomas occurring in the familial multiple endocrine neoplasia type 1 (MEN-1) syndrome.