RT Journal Article SR Electronic T1 Immunohistochemical demonstration of neurone specific enolase in bone marrow infiltrated by neuroblastoma. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 309 OP 312 DO 10.1136/jcp.44.4.309 VO 44 IS 4 A1 J M Caillaud A1 F Martinez-Madrigal A1 O Hartmann A1 C Carlu YR 1991 UL http://jcp.bmj.com/content/44/4/309.abstract AB One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's disease and two lymphoblastic lymphomas. Twenty seven (32%) of neuroblastoma bone marrows showed metastases by conventional histological techniques and 33 (39%) after immunohistochemical staining with NSE. Five embryonal rhabdomyosarcomas, five Ewing's sarcomas, and two lymphoblastic lymphomas showed bone marrow metastases. Only one of these cases was reactive for NSE. NSE represents a very sensitive immunomarker for the follow up of neuroblastoma and improves detection of bone marrow invasion by neuroblastoma.