PT  - JOURNAL ARTICLE
AU  - Sumiyoshi, Y
AU  - Kikuchi, M
AU  - Ohshima, K
AU  - Takeshita, M
AU  - Eizuru, Y
AU  - Minamishima, Y
TI  - Analysis of human herpes virus-6 genomes in lymphoid malignancy in Japan.
AID  - 10.1136/jcp.46.12.1137
DP  - 1993 Dec 01
TA  - Journal of Clinical Pathology
PG  - 1137--1138
VI  - 46
IP  - 12
4099  - http://jcp.bmj.com/content/46/12/1137.short
4100  - http://jcp.bmj.com/content/46/12/1137.full
SO  - J Clin Pathol1993 Dec 01; 46
AB  - Ninety cases of malignant lymphoma and 56 cases of reactive lymphadenopathy were studied using Southern blot analysis and the polymerase chain reaction to identify human herpes virus-6 (HHV-6) DNA. This was detected in cases of lymphoid malignancy at a rate which ranged from 50.0% to 68.8%. There were no differences in rates for different types of lymphoid malignancies. Herpes virus-6 DNA was detected by PCR in lymphoid malignancies less frequently than in reactive lymphadenopathies. It was not detected in lymphoid malignancies using Southern blotting. These results suggest that HHV-6 DNA was not related to lymphoid malignancy and was only a latent infection of non-neoplastic cells in tumour tissue.